Overall, this study is the first large scale analysis of a major signalling gene superfamily in the hemichordate lineage. However, the peptide and somatostatin binding receptors have expanded locally in the acorn worm. The Rhodopsin family has fewer members than vertebrates and lacks clear homologues for 6 of the 13 subgroups, including olfactory, chemokine, prostaglandin, purine, melanocyte concentrating hormone receptors and MAS-related receptors. kowalevskii is around 47%, and this is same as observed in couple of the closest vertebrate relatives, Ciona intestinalis (41%) and Branchiostoma floridae (~47%). The average sequence identity between the GPCR orthologues in human and S.
This is particularly true for genes involved in CNS development and regulation in vertebrates. Despite having a diffuse nervous system, the acorn worm contains well conserved orthologues for human Adhesion and Glutamate family members, with a similar N-terminal domain architecture. Here, we identified 260 unique GPCRs and classified as many as 257 of them into five main mammalian GPCR families Glutamate (23), Rhodopsin (212), Adhesion (18), Frizzled (3) and Secretin (1).
Despite being such an important model organism, the signalling system repertoire of the largest family of integral transmembrane receptor proteins, G protein-coupled receptors (GPCRs) is largely unknown in S. kowalevskii has chordate like morphological traits and serves as an important model organism, helping developmental biologists to understand the evolution of the central nervous system (CNS). Hemichordates are sister group to echinoderms, and closely related to chordates.
Saccoglossus kowalevskii (the acorn worm) is a hemichordate belonging to the superphylum of deuterostome bilateral animals.
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